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NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension

Aripiprazole was administered for 2 years in the diet at doses of 1, 3, 10, and 30 mg/kg/day to ICR mice and 1, 3, and 10 mg/kg/day to F344 rats (0.2 to 5 times and 0.3 to 3 times the oral MRHD of 30 mg/day based on body surface area (mg/m2), respectively)

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Allergic reactions are also possible but uncommon